منابع مشابه
Broad-spectrum antiviral that interferes with de novo pyrimidine biosynthesis.
Compound A3 was identified in a high-throughput screen for inhibitors of influenza virus replication. It displays broad-spectrum antiviral activity, and at noncytotoxic concentrations it is shown to inhibit the replication of negative-sense RNA viruses (influenza viruses A and B, Newcastle disease virus, and vesicular stomatitis virus), positive-sense RNA viruses (Sindbis virus, hepatitis C vir...
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AIMS The endothelium represents a natural site of human cytomegalovirus (HCMV) infection involved in viral spreading and persistence. Moreover, HCMV infection of endothelial cells has been associated with different pathological conditions of the cardiovascular system. Here, the influence of the antiepileptic drug valproic acid (VPA) was investigated on HCMV replication in human umbilical vein e...
متن کاملAntimicrobial defences increase with sociality in bees.
Evidence for the antiquity and importance of microbial pathogens as selective agents is found in the proliferation of antimicrobial defences throughout the animal kingdom. Social insects, typified by crowding and often by low genetic variation, have high probabilities of disease transmission and eusocial Hymenoptera may be particularly vulnerable because of haplodiploidy. Mechanisms they employ...
متن کاملAntiviral Innate Immune Response Interferes with the Formation of Replication-Associated Membrane Structures Induced by a Positive-Strand RNA Virus
Infection with nidoviruses like corona- and arteriviruses induces a reticulovesicular network of interconnected endoplasmic reticulum (ER)-derived double-membrane vesicles (DMVs) and other membrane structures. This network is thought to accommodate the viral replication machinery and protect it from innate immune detection. We hypothesized that the innate immune response has tools to counteract...
متن کاملPriming of indirect defences.
Leaf damage induces in many plant species the secretion of extrafloral nectar (EFN) and/or the release of specific odours (volatile organic compounds, VOCs). Both traits attract carnivorous arthropods and function as indirect plant defences by increasing the predation pressure on attacking herbivores. We have conducted field experiments in Mexico and found that plants that had been exposed to V...
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ژورنال
عنوان ژورنال: Nature Cell Biology
سال: 2017
ISSN: 1465-7392,1476-4679
DOI: 10.1038/ncb3502